Sympathetic Modulation of the Host Defense Response to Infectious Challenge during Recovery from Hemorrhage

摘要

BackgroundTrauma/hemorrhage (TxHem) is associated with an immediate pro-inflammatory response that, if exaggerated or prolonged, is thought to contribute to the subsequent immunosuppression that characterizes the period after injury. Previously we have demonstrated that chemical sympathectomy (SNSx) accentuates this immediate pro-inflammatory response to TxHem. These findings suggest that the noradrenergic system plays a critical role in limiting the magnitude of the inflammatory response during TxHem and preserving the integrity of the host defense response to a subsequent infectious challenge during the period after TxHem. Objective: To examine the contribution of tissue norepinephrine to the host defense response to an infectious challenge during recovery from TxHem.