Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S a sperm-specific glycolytic enzyme

摘要

STUDY HYPOTHESISDetailed structural comparisons of sperm-specific glyceraldehyde 3-phosphate dehydrogenase, spermatogenic (GAPDHS) and the somatic glyceraldehyde 3-phosphate dehydrogenase (GAPDH) isozyme should facilitate the identification of selective GAPDHS inhibitors for contraceptive development.