Functional lung avoidance and response-adaptive escalation (FLARE) RT: multimodality plan dosimetry of a precision radiation oncology strategy

摘要

PurposeNon-small cell lung cancer (NSCLC) patient radiation therapy (RT) is planned without consideration of spatial heterogeneity in lung function or tumor response. We assessed the dosimetric and clinical feasibility of functional lung avoidance and response-adaptive escalation (FLARE) RT to reduce dose to [^99mTc]MAA-SPECT/CT perfused lung while redistributing an escalated boost dose within [¹⁸F]FDG-PET/CT-defined biological target volumes (BTV).