In vivo characterization of four 68Ga-labelled multimeric RGD peptides to image αvβ3 integrin expression in two human tumour xenograft mouse models

摘要

Rationaleαvβ3 integrins play an important role in angiogenesis and cell migration of tumours. They are highly expressed on activated endothelial cells of newly formed blood vessels. Here, we compare the targeting characteristics of four ⁶⁸Ga-labelled multimeric cyclic RGD-based tracers in an αvβ3 integrin-expressing tumour model and in a tumour model where αvβ3 integrin is expressed solely on the neovasculature.