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A Randomized Trial to Compare the Safety Tolerability and Effectiveness of 3 Antimalarial Regimens for the Prevention of Malaria in Nigerian Patients With Sickle Cell Disease

机译：一项比较3种抗疟疾药物在尼日利亚镰状细胞病患者中预防疟疾的安全性耐受性和有效性的随机试验

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BackgroundMalaria prophylaxis is recommended for persons with sickle cell disease (SCD), but the value of this has been questioned. The aim of this study was to find out whether intermittent preventive treatment (IPT) with a fixed-dose combination of mefloquine-artesunate (MQAS) or sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) was more effective than daily proguanil for malaria prevention in subjects with SCD.

机译：背景技术建议对镰状细胞病（SCD）的患者进行疟疾预防，但其价值受到质疑。这项研究的目的是要发现，固定剂量的甲氧喹啉-青蒿琥酯（MQAS）或磺胺多辛-乙胺嘧啶加氨二喹（SPAQ）的固定剂量组合进行的间歇性预防治疗（IPT）是否比每日异丙酚对预防疟疾的受试者更有效SCD。

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期刊名称 The Journal of Infectious Diseases
作者
Rasaq Olaosebikan; Kolade Ernest; Kalifa Bojang; Olugbenga Mokuolu; Andrea M. Rehman; Muna Affara; Davis Nwakanma; Jean-René Kiechel; Taofik Ogunkunle; Tope Olagunju; Rukayat Murtala; Peter Omefe; Tosin Lambe; Surajudeen Bello; Olayinka Ibrahim; Benedict Olorunsola; Ayotade Ojuawo; Brian Greenwood; Paul Milligan;
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作者单位

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年(卷),期 -1(212),4
年度 -1
页码 617–625
总页数 9
原文格式 PDF
正文语种
中图分类免疫学 ; 微生物学 ; 病毒传染病 ;
关键词
sickle cell disease malaria chemoprevention intermittent preventive treatment prophylaxis mefloquine-artesunate proguanil;

机译：镰状细胞病;疟疾;化学预防;间歇性预防性治疗;预防;甲氟喹青蒿琥酯;氯胍;

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专利

1. A Randomized Trial to Compare the Safety, Tolerability, and Effectiveness of 3 Antimalarial Regimens for the Prevention of Malaria in Nigerian Patients With Sickle Cell Disease [J] . Olaosebikan Rasaq, Ernest Kolade, Bojang Kalifa, The Journal of Infectious Diseases . 2015 ,第4期

机译：一项比较3种抗疟疾药物在尼日利亚镰状细胞病患者中预防疟疾的安全性，耐受性和有效性的随机试验
2. Protective Efficacy and Safety of Three Antimalarial Regimens for the Prevention of Malaria in Young Ugandan Children: A Randomized Controlled Trial [J] . Victor Bigira, James Kapisi, Tamara D. Clark, PLoS Medicine . 2014 ,第8期

机译：三种预防疟疾预防乌干达儿童疟疾的保护性和安全性：一项随机对照试验。
3. Protective Efficacy and Safety of Three Antimalarial Regimens for the Prevention of Malaria in Young Ugandan Children: A Randomized Controlled Trial [J] . Victor Bigira, James Kapisi, Tamara D. Clark, PLoS Medicine . 2014 ,第8期

机译：三种预防疟疾预防乌干达儿童疟疾的保护性和安全性：一项随机对照试验。
4. Effectiveness of various regimens of maintaining anti-inflammatory therapy in mild to moderate asthmatic children: results of the prospective multicenter randomized trial [C] . Tereshchenko S., Smirnova S., Novitckii I., World Asthma, Allergy COPD Forum . 2014

机译：各种方案在轻度至中度哮喘儿童中维持抗炎治疗方案的有效性：前瞻性多中心随机试验的结果
5. Results of a randomized, controlled trial to assess the toxicity and patient adherence with two short-course regimens for the prevention of tuberculosis, a two-month regimen of rifampin and pyrazinamide or a four-month regimen of rifampin only, in comparison with a control regimen of six-months-isoniazid. [D] . Geiter, Lawrence James. 1997

机译：与对照相比，采用两种短期疗程预防结核病，两个月利福平和吡嗪酰胺治疗或仅四个月利福平治疗，评估毒性和患者依从性的随机对照试验结果六个月异烟肼的治疗方案。
6. Protective Efficacy and Safety of Three Antimalarial Regimens for the Prevention of Malaria in Young Ugandan Children: A Randomized Controlled Trial [O] . Victor Bigira, James Kapisi, Tamara D. Clark, 2014

机译：三种预防疟疾预防乌干达儿童疟疾的保护性和安全性：一项随机对照试验。
7. Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial. [O] . Victor Bigira, James Kapisi, Tamara D Clark, 2014

机译：三种抗疟方案对乌干达年轻儿童疟疾预防的保护效果和安全性：一项随机对照试验。

A Randomized Trial to Compare the Safety Tolerability and Effectiveness of 3 Antimalarial Regimens for the Prevention of Malaria in Nigerian Patients With Sickle Cell Disease

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