Increased Expression of Cathepsins and Obesity-Induced Proinflammatory Cytokines in Lacrimal Glands of Male NOD Mouse

机译：组织NOS小鼠泪腺组织蛋白酶和肥胖诱导的促炎细胞因子的表达增加。

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Purpose.Lacrimal glands (LGs) of male NOD mice, a model of Sjögren's syndrome (SjS), exhibit immune cell infiltration and lipid deposition. The mechanism of SjS was further investigated by characterizing gene expression profiles of NOD mouse LGs in comparison with those of healthy control mice. Differentially expressed genes were further investigated at the protein level to correlate changes in location and abundance with development of disease.

机译：目的：雄性NOD小鼠的泪腺（LG）是干燥综合征（SjS）的模型，表现出免疫细胞浸润和脂质沉积。通过表征NOD小鼠LG与健康对照小鼠的基因表达谱，进一步研究了SjS的机制。在蛋白质水平上进一步研究了差异表达的基因，以将位置和丰度的变化与疾病的发展相关联。

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期刊名称 Investigative Ophthalmology Visual Science
作者
Xiaodong Li; Kaijin Wu; Maria Edman; Katja Schenke-Layland; Michelle MacVeigh-Aloni; Srikanth Reddy Janga; Barbara Schulz; Sarah F. Hamm-Alvarez;
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作者单位

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年(卷),期 -1(51),10
年度 -1
页码 5019–5029
总页数 11
原文格式 PDF
正文语种
中图分类眼科学;
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专利

1. Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse. [J] . Li X, Wu K, Edman M, Investigative ophthalmology & visual science . 2010,第10期

机译：组织蛋白酶和肥胖诱导的雄性NOD小鼠泪腺中的促炎性细胞因子的表达增加。
2. Increased Expression of Cathepsins and Obesity-Induced Proinflammatory Cytokines in Lacrimal Glands of Male NOD Mouse [J] . Xiaodong Li, Kaijin Wu, Maria Edman, Investigative ophthalmology & visual science . 2010,第10期

机译：组织NOS小鼠泪腺组织蛋白酶和肥胖诱导的促炎细胞因子的表达增加。
3. Increased Expression of Cathepsins and Obesity-Induced Proinflammatory Cytokines in Lacrimal Glands of Male NOD Mouse [J] . Xiaodong Li, Kaijin Wu, Maria Edman, Investigative ophthalmology & visual science . 2010,第10期

机译：组织NOS小鼠泪腺组织蛋白酶和肥胖诱导的促炎细胞因子的表达增加。
4. Self-assembled multifunctional nanogel reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells [C] . Rui Li, Kiara Bruggeman, David R Nisbet, World biomaterials congress . 2016

机译：自组装多功能纳米凝胶可降低促炎细胞因子的表达，从而诱导上皮癌细胞的凋亡
5. Up-regulation of inflammatory cytokines in the lacrimal glands of a predisposed mouse model of Sjogren's Syndrome (SS): The influence of sex hormones and a newly proposed mechanism for SS. [D] . Czerwinski, Stefanie P.C. 2013

机译：干燥综合征干燥小鼠模型（SS）的泪腺炎性细胞因子的上调：性激素的影响和新提出的SS机制。
6. Interferon-γ treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjögren’s Syndrome [O] . Zhen Meng, Wannita Klinngam, Maria C. Edman, 2011

机译：赛格伦综合征的NOD小鼠模型在体外干扰素-γ处理引起组织蛋白酶S和泪腺和角膜抗原呈递特征的某些变化
7. Increased Expression of Cathepsins and Obesity-Induced Proinflammatory Cytokines in Lacrimal Glands of Male NOD Mouse [O] . Li, Xiaodong, Wu, Kaijin, Edman, Maria, 2010

机译：组织NOS小鼠泪腺组织蛋白酶和肥胖诱导的促炎细胞因子的表达增加。

Increased Expression of Cathepsins and Obesity-Induced Proinflammatory Cytokines in Lacrimal Glands of Male NOD Mouse

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