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Imatinib for Melanomas Harboring Mutationally Activated or Amplified KIT Arising on Mucosal Acral and Chronically Sun-Damaged Skin

机译：伊马替尼用于黑色素瘤的黏膜唾液酸和慢性日晒损伤皮肤上的突变激活或扩增的KIT

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PurposeAmplifications and mutations in the KIT proto-oncogene in subsets of melanomas provide therapeutic opportunities.

机译：目的黑色素瘤子集中的KIT原癌基因中的扩增和突变提供了治疗机会。

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期刊名称 Journal of Clinical Oncology
作者
F. Stephen Hodi; Christopher L. Corless; Anita Giobbie-Hurder; Jonathan A. Fletcher; Meijun Zhu; Adrian Marino-Enriquez; Philip Friedlander; Rene Gonzalez; Jeffrey S. Weber; Thomas F. Gajewski; Steven J. ODay; Kevin B. Kim; Donald Lawrence; Keith T. Flaherty; Jason J. Luke; Frances A. Collichio; Marc S. Ernstoff; Michael C. Heinrich; Carol Beadling; Katherine A. Zukotynski; Jeffrey T. Yap; Annick D. Van den Abbeele; George D. Demetri; David E. Fisher;
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年(卷),期 -1(31),26
年度 -1
页码 3182–3190
总页数 12
原文格式 PDF
正文语种
中图分类肿瘤学;
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专利

1. Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin. [J] . F Stephen Hodi, Christopher L Corless, Anita Giobbie-Hurder, Journal of Clinical Oncology . 2013,第26期

机译：伊马替尼用于黑色素瘤，该黑色素瘤具有在粘膜，唾液和长期阳光照射的皮肤上产生的突变激活或扩增的KIT。
2. KIT amplification and gene mutations in acral/mucosal melanoma in Korea. [J] . Yun J, Lee J, Jang J, APMIS: Acta Pathologica, Microbiologica et Immunologica Scandinavica . 2011,第6期

机译：韩国端/粘膜黑色素瘤的KIT扩增和基因突变。
3. Phase II, Open-Label, Single-Arm Trial of Imatinib Mesylate in Patients With Metastatic Melanoma Harboring c-Kit Mutation or Amplification. [J] . Guo J, Si L, Kong Y, Journal of Clinical Oncology . 2011,第21期

机译：甲磺酸伊马替尼在具有c-Kit突变或扩增的转移性黑色素瘤患者中进行的II期，开放标签，单臂试验。
4. Detection of de novo IGHV mutations by ultra-deep sequencing from in vitro activated B-cell chronic lymphocytic leukemia cells: Evidence for activation-induced deaminase function [C] . Chu C.C., Patten P.E.M., MacCarthy T, International Congress of Immunology. . 2014

机译：通过来自体外活化B细胞慢性淋巴细胞白血病细胞超深序的De Novo IghV突变检测：活化诱导的脱氨酶功能的证据
5. Mechanism of transformation and therapeutic targets for hematological neoplasms harboring oncogenic KIT mutation. [D] . Martin, Holly Rene. 2014

机译：具有致癌性KIT突变的血液肿瘤的转化机制和治疗靶标。
6. Correlation between KIT expression and KIT mutation in melanoma: a study of 173 cases with emphasis on the acral-lentiginous/mucosal type [O] . Carlos A Torres-Cabala, Wei-Lien Wang, Jonathan Trent, -1

机译：黑素瘤试剂素表达与试剂盒突变的相关性：对急性/粘膜型重点重点的173例研究
7. Imatinib for Melanomas Harboring Mutationally Activated or Amplified KIT Arising on Mucosal, Acral, and Chronically Sun-Damaged Skin [O] . F. Stephen Hodi, Christopher L. Corless, Anita Giobbie-Hurder, 2013

机译：Melanomas的伊马替尼含有在粘膜，轴，慢性损伤皮肤上产生的变更活化或扩增的试剂盒

Imatinib for Melanomas Harboring Mutationally Activated or Amplified KIT Arising on Mucosal Acral and Chronically Sun-Damaged Skin

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