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Efficacy and Safety of Insulin Degludec in a Flexible Dosing Regimen vs Insulin Glargine in Patients With Type 1 Diabetes (BEGIN: Flex T1): A 26-Week Randomized Treat-to-Target Trial With a 26-Week Extension

机译：灵活的给药方案与甘精胰岛素在1型糖尿病患者中的有效性和安全性（BEGIN：Flex T1）：26周随机靶向治疗试验延长26周

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摘要

Objective:This study investigated the efficacy and safety of insulin degludec (IDeg) once daily (OD), varying injection timing day to day in subjects with type 1 diabetes.

机译：目的：本研究调查了每天一次（OD）每天一次的degdegc胰岛素（IDeg）的疗效和安全性，并每天改变1型糖尿病患者的注射时间。

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期刊名称 The Journal of Clinical Endocrinology and Metabolism
作者
Chantal Mathieu; Priscilla Hollander; Bresta Miranda-Palma; John Cooper; Edward Franek; David Russell-Jones; Jens Larsen; Søren Can Tamer; Stephen C. Bain;
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年(卷),期 -1(98),3
年度 -1
页码 1154–1162
总页数 1
原文格式 PDF
正文语种
中图分类基础医学;
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1. Efficacy and Safety of Insulin Degludec in a Flexible Dosing Regimen vs Insulin Glargine in Patients With Type 1 Diabetes (BEGIN: Flex T1): A 26-Week Randomized, Treat-to-Target Trial With a 26-Week Extension [J] . Chantal Mathieu, Priscilla Hollander, Bresta Miranda-Palma, The journal of clinical endocrinology and metabolism . 2013,第3期

机译：灵活的给药方案与甘精胰岛素在1型糖尿病患者中的疗效和安全性（BEGIN：Flex T1）：26周随机，靶向治疗试验，延长26周
2. The efficacy and safety of insulin degludec given in variable once-daily dosing intervals compared with insulin glargine and insulin degludec dosed at the same time daily: A 26-week, randomized, open-label, parallel-group, treat-to-target trial in individuals with type 2 diabetes [J] . MeneghiniL., AtkinS.L., GoughS.C.L., Diabetes care . 2013,第4期

机译：与每日一次同时给药的甘精胰岛素和地格列松胰岛素相比，以每天一次的可变给药间隔给予地格列松胰岛素的疗效和安全性：一项为期26周，随机，开放标签，平行组，以治疗为目标的试验在2型糖尿病患者中
3. The efficacy and safety of insulin degludec given in variable once-daily dosing intervals compared with insulin glargine and insulin degludec dosed at the same time daily: A 26-week, randomized, open-label, parallel-group, treat-to-target trial in individuals with type 2 diabetes [J] . MeneghiniL., AtkinS.L., GoughS.C.L., Diabetes care . 2013,第4期

机译：胰岛素Degludec在可变的胰岛素中给药的疗效和安全性与胰岛素狼狼和胰岛素Degludec在每日同时给药：26周，随机，开放标签，平行组，治疗对目标试验在2型糖尿病的个体中
4. Switching to insulin glargine 300 U/mL from other basal insulin analogues provides less 24-hour glucose variability in hospitalized patients with type 1 diabetes [C] . V.V. Klimontov, E.A. Koroleva, O.N. Fazullina International Multiconference Bioinformatics of Genome Regulation and StructureSystems Biology . 2018

机译：从其他基础胰岛素类似物转换为甘精胰岛素300 U / mL可使住院的1型糖尿病患者的24小时葡萄糖变异性降低
5. A 4-month randomized controlled clinical trial of adjuvant Exenatide or Pramlintide versus insulin alone in pediatric type 1 diabetes mellitus: Effect on glycemic control. [D] . Withycombe, Sarah Elizabeth. 2010

机译：儿科1型糖尿病患者中艾塞那肽或普兰林肽与单独使用胰岛素的4个月随机对照临床试验：对血糖控制的影响。
6. Efficacy and safety of insulin degludec given as part of basal–bolus treatment with mealtime insulin aspart in type 1 diabetes: a 26-week randomized open-label treat-to-target non-inferiority trial [O] . M J Davies, J L Gross, Y Ono, -1

机译：在1型糖尿病患者中就餐时给予门冬胰岛素作为基础推注治疗的一部分药物以地格曲胰岛素的有效性和安全性为研究对象：一项为期26周的开放性靶向治疗的非劣效性试验
7. Efficacy and Safety of Insulin Degludec in a Flexible Dosing Regimen vs Insulin Glargine in Patients With Type 1 Diabetes (BEGIN: Flex T1): A 26-Week Randomized, Treat-to-Target Trial With a 26-Week Extension [O] . Bain, Steve 2013

机译：胰岛素degludec在1型糖尿病患者中的灵活给药方案与胰岛素甘精胰岛素的疗效和安全性（BEGIN：Flex T1）：26周随机，治疗目标试验，延长26周

Efficacy and Safety of Insulin Degludec in a Flexible Dosing Regimen vs Insulin Glargine in Patients With Type 1 Diabetes (BEGIN: Flex T1): A 26-Week Randomized Treat-to-Target Trial With a 26-Week Extension

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