Trabecular Structure Quantified With the MRI-Based Virtual Bone Biopsy in Postmenopausal Women Contributes to Vertebral Deformity Burden Independent of Areal Vertebral BMD

摘要

In postmenopausal women with a wide range of vertebral deformities, MRI-based structural measures of topology and scale at the distal radius are shown to account for as much as 30% of vertebral deformity, independent of integral vertebral BMD.IntroductionTrabecular bone architecture has been postulated to contribute to overall bone strength independent of vertebral BMD measured by DXA. However, there has thus far been only sparse in vivo evidence to support this hypothesis.