Association of Serum Fibroblast Growth Factor 23 (FGF23) and incident fractures in older men: the Osteoporotic Fractures in Men (MrOS) Study

摘要

Normal mineral metabolism is critical for skeletal integrity and recently serum fibroblast Growth factor 23 (FGF23) levels were found to be directly related to overall fracture risk in elderly Swedish Men. To confirm this association, we performed a prospective case-cohort study to understand the relation of FGF23 and fracture risk in older Caucasian men enrolled in the Osteoporotic Fractures in Men (MrOS) Study.MethodsIn the cohort of 5994 men attending the baseline MrOS examination, we evaluated a subgroup of 387 men with incident nonvertebral fracture including 73 hip fractures and a sample of 1385 men randomly selected from the cohort with baseline mineral and calcium hormone measurements. FGF23 was measured in baseline serum samples by ELISA (Millipore, Billerica, MA). Modified Cox proportional hazards models that account for case cohort study design were used to estimate the relative hazards (RH) of fracture in men across quartiles of FGF23. Subjects were also stratified by renal function and RH per strata was estimated in men with the highest quartile of FGF23 compared to quartile 3, 2 and 1.