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AMP-18 Facilitates Assembly and Stabilization of Tight Junctions to Protect the Colonic Mucosal Barrier

机译：AMP-18有助于组装和牢固连接以保护结肠粘膜屏障

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BackgroundInflammatory bowel disease (IBD) is characterized by an injured epithelium. Development of agents that could enhance mucosal healing is a major goal in IBD therapeutics. The 18-kDa antrum mucosal protein (AMP-18) and a 21-mer peptide derived from AMP-18, stimulate accumulation of tight junction (TJ) proteins in cultured epithelial cells and mouse colonic mucosa to protect the mucosal barrier, suggesting it might be a useful agent to treat IBD.

机译：背景炎症性肠病（IBD）的特征是上皮受损。可以增强粘膜愈合的药物的开发是IBD治疗的主要目标。 18 kDa胃窦粘膜蛋白（AMP-18）和一种源自AMP-18的21-mer肽，刺激培养的上皮细胞和小鼠结肠粘膜中紧密连接（TJ）蛋白的积累，以保护粘膜屏障，表明它可能成为治疗IBD的有用药物。

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期刊名称 Inflammatory Bowel Diseases
作者
Peili Chen; Sreedharan Kartha; Marc Bissonnette; John Hart; F. Gary Toback;
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作者单位

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年(卷),期 -1(18),9
年度 -1
页码 1749–1759
总页数 21
原文格式 PDF
正文语种
中图分类肠道病毒与肝炎病毒;肝及胆疾病;肠疾病;
关键词
Antrum Mucosal Protein (AMP)-18 IBD Tight Junctions p38 mitogen activated protein kinase PKCζ;

机译：胃黏膜蛋白（AMP）-18;IBD;紧密连接;p38丝裂原活化蛋白激酶;PKCζ;

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专利

1. AMP-18 facilitates assembly and stabilization of tight junctions to protect the colonic mucosal barrier [J] . ChenP., KarthaS., BissonnetteM., Inflammatory bowel diseases . 2012,第9期

机译：AMP-18有助于组装和稳定紧密连接，以保护结肠粘膜屏障
2. AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins. [J] . Walsh Reitz MM, Huang EF, Musch MW, American Journal of Physiology . 2005,第1期

机译：AMP-18保护结肠上皮细胞的屏障功能：紧密连接蛋白的作用。
3. Musca domestica Cecropin (Mdc) Alleviates Salmonella typhimurium-Induced Colonic Mucosal Barrier Impairment: Associating With Inflammatory and Oxidative Stress Response, Tight Junction as Well as Intestinal Flora [J] . Lun Zhang, Shuiqing Gui, Zhaobo Liang, Frontiers in Microbiology . 2019,第6期

机译：家蝇 Cecropin（Mdc）减轻鼠伤寒沙门氏菌引起的结肠粘膜屏障障碍：与炎症和氧化应激反应，紧密连接以及肠道菌群有关
4. Inhibition of electrogenic ion transport in rat colonic mucosae by zinc is enabled by the tight junction opener, cytochalasin D [C] . V. Bzik, C. Sheridan, D. J. Brayden Annual meeting exposition of the Controlled Release Society . 2010

机译：锌通过紧密连接开启子细胞松弛素D抑制大鼠结肠粘膜中的电致离子运输
5. The Effect of Moderate and Deep Hypothermia on Blood-Brain Barrier Integrity and Tight Junction Protein Expression [D] . Fu, Tianhong. 2021

机译：中等和深低温对血脑屏障完整性和紧密结蛋白表达的影响
6. AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins [O] . Margaret M. Walsh-Reitz, Erick F. Huang, Mark W. Musch, -1

机译：AMP-18保护结肠上皮细胞的屏障功能：紧密连接蛋白的作用
7. AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins [O] . Margaret M. Walsh-Reitz, Erick F. Huang, Mark W. Musch, 2005

机译：AMP-18保护结肠上皮细胞的阻隔功能：紧密结蛋白的作用

AMP-18 Facilitates Assembly and Stabilization of Tight Junctions to Protect the Colonic Mucosal Barrier

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