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Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy

机译：氧诱导的缺血性视网膜病和增生性糖尿病性视网膜病中12-脂氧合酶的表达和活性增加

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摘要

OBJECTIVEArachidonic acid is metabolized by 12-lipoxygenase (12-LOX) to 12-hydroxyeicosatetraenoic acid (12-HETE) and has an important role in the regulation of angiogenesis and endothelial cell proliferation and migration. The goal of this study was to investigate whether 12-LOX plays a role in retinal neovascularization (NV).

机译：目的花生四烯酸被12-脂氧合酶（12-LOX）代谢为12-羟基二十碳四烯酸（12-HETE），并且在调节血管生成和内皮细胞增殖和迁移中起重要作用。这项研究的目的是调查12-LOX是否在视网膜新生血管形成（NV）中起作用。

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期刊名称 Diabetes
作者
Mohamed Al-Shabrawey; Rene Mussell; Khalid Kahook; Amany Tawfik; Mohamed Eladl; Vijay Sarthy; Julian Nussbaum; Ahmed El-Marakby; Sun Young Park; Zafer Gurel; Nader Sheibani; Krishna Rao Maddipati;
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年(卷),期 2011(60),2
年度 2011
页码 614–624
总页数 11
原文格式 PDF
正文语种
中图分类基础医学;
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1. Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy: Implications in Retinal Neovascularization [J] . Mohamed Al-Shabrawey Rene Mussell Khalid Kahook Amany Tawfik Mohamed Eladl Vijay Sarthy Julian Nussbaum Ahmed El-Marakby Sun Young Park Zafer Gurel Nader Sheibani Krishna Rao Maddipati Diabetes . 2011,第2期

机译：氧诱导的缺血性视网膜病和增生性糖尿病性视网膜病中12-脂氧合酶的表达和活性增加：视网膜新生血管的影响。
2. Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy [J] . Mohamed Al-Shabrawey, Rene Mussell, Khalid Kahook, Diabetes . 2011,第2期

机译：氧诱导的缺血性视网膜病和增生性糖尿病性视网膜病中12-脂氧合酶的表达和活性增加
3. Overexpression of 15-lipoxygenase-1 in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via downregulation of vascular endothelial growth factor-A expression [J] . Chen Zhen, Du Ke, He Tao, Molecular vision . 2012,第2012期

机译：氧诱导的缺血性视网膜病中15-脂氧合酶-1的过表达通过下调血管内皮生长因子-A的表达抑制视网膜新血管形成
4. Determination of Non-Proliferative and Proliferative Diabetic Retinopathy through Fundoscopy using Principal Component Analysis [C] . Carlos C. Hortinela, Jessie R. Balbin, Glenn V. Magwili, International Conference on Humanoid, Nanotechnology, Information Technology, Communication and Control, Environment, and Management . 2020

机译：利用主成分分析测定通过基底诊断的非增殖性和增殖性糖尿病视网膜病变
5. Effect of intravitreal or sub-tenon triamcinolone acetonide injection at completion of vitrectomy on peripheral retinochoroidal thickness in eyes with proliferative diabetic retinopathy [D] . Fujiwara Yoshito, 藤原圭人 2019

机译：玻璃体切除术完成后玻璃体内或肌腱下注射丙酮酸曲安奈德对增生性糖尿病性视网膜病变的眼睛周围脉络膜脉络膜厚度的影响
6. Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization. Diabetes 2011;60:614–624 [O] . M Al-Shabrawey, R Mussell, K Kahook, 2013

机译：氧诱导的缺血性视网膜病变和增生性糖尿病性视网膜病变中12-脂氧合酶的表达和活性增加：视网膜新生血管形成的影响。糖尿病2011; 60：614–624
7. Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy: Implications in Retinal Neovascularization [O] . Al-Shabrawey, Mohamed, Mussell, Rene, Kahook, Khalid, 2011

机译：氧诱导的缺血性视网膜病和增生性糖尿病性视网膜病中12-脂氧合酶的表达和活性增加：视网膜新生血管的影响。

Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy

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