Erken, Haydar Ali, Gülten Erken, Ridvan Çolak, Osman Genç. Exercise and DHA prevent the negative effects of hypoxia on EEG and nerve conduction velocity. High Alt Med Biol 14:360–366, 2013.—It is known that hypoxia has a negative effect on nervous system functions, but exercise and DHA (docosahexaenoic acid) have positive effect. In this study, it was investigated whether exercise and/or DHA can prevent the effects of hypoxia on EEG and nerve conduction velocity (NCV). 35 adult Wistar albino male rats were divided into five groups (n=7): control (C), hypoxia (H), hypoxia and exercise (HE), hypoxia and DHA (HD), and hypoxia and exercise and DHA (HED) groups. During the 28-day hypoxia exposure, the HE and HED groups of rats were exercised (0% incline, 30 m/min speed, 20 min/day, 5 days a week). In addition, DHA (36 mg/kg/day) was given by oral gavage to rats in the HD and HED groups. While EEG records were taken before and after the experimental period, NCV records were taken after the experimental period from anesthetized rats. Data were analyzed by paired t-test, one-way ANOVA, and post hoc Tukey test. In this study, it was shown that exposure to hypoxia decreased theta activity and NCV, but exercise and DHA reduced the delta activity, while theta, alpha, beta activities, and NCV were increased. These results have shown that the effects of hypoxia exposure on EEG and NCV can be prevented by exercise and/or DHA.
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机译：Erken，Haydar Ali，GültenErken，RidvanÇolak，OsmanGenç。运动和DHA可防止缺氧对脑电图和神经传导速度的负面影响。 High Alt Med Biol 14：360–366，2013年。—已知缺氧对神经系统功能有负面影响，但运动和DHA（二十二碳六烯酸）则有积极作用。在这项研究中，研究了运动和/或DHA是否可以预防缺氧对脑电图和神经传导速度（NCV）的影响。将35只成年Wistar白化病雄性大鼠分为五组（n = 7）：对照（C），低氧（H），低氧与运动（HE），低氧与DHA（HD），低氧与运动与DHA（HED）组。在缺氧28天期间，HE和HED组的大鼠进行了运动（0％倾斜，30μm/ min的速度，20μmin/天，每周5天）。另外，在HD和HED组中，通过口服强饲法给予大鼠DHA（36 mg / kg /天）。在实验期间之前和之后记录脑电图，在实验期间之后从麻醉大鼠中获取NCV记录。通过配对t检验，单向方差分析和事后Tukey检验分析数据。在这项研究中，表明缺氧暴露会降低theta活性和NCV，但是运动和DHA会降低delta活性，而theta，α，β活性和NCV会增加。这些结果表明，通过运动和/或DHA可以预防缺氧暴露对EEG和NCV的影响。
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