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Extensive innate immune gene activation accompanies brain aging increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

机译：一项微阵列研究显示广泛的先天免疫基因激活伴随大脑衰老增加了对认知功能减退和神经变性的脆弱性

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摘要

BackgroundThis study undertakes a systematic and comprehensive analysis of brain gene expression profiles of immune/inflammation-related genes in aging and Alzheimer’s disease (AD).

机译：背景这项研究对衰老和阿尔茨海默氏病（AD）中免疫/炎症相关基因的大脑基因表达谱进行了系统，全面的分析。

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期刊名称 Journal of Neuroinflammation
作者
David H Cribbs; Nicole C Berchtold; Victoria Perreau; Paul D Coleman; Joseph Rogers; Andrea J Tenner; Carl W Cotman;
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作者单位

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年(卷),期 2012(9),-1
年度 2012
页码 179
总页数 18
原文格式 PDF
正文语种
中图分类神经科学 ;
关键词
Complement Toll-like receptor Inflammasome Cryopyrin Caspase-1 Myeloid-related protein Calgranulin Calprotectin Alarmin Endogenous danger signaling Fractalkine;

机译：补体;Toll样受体;炎性体;隐索蛋白;Caspase-1;髓样相关蛋白;钙粒蛋白;钙卫蛋白;警报蛋白;内源性危险信号;Fractalkine;

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专利

1. Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study [J] . David H Cribbs, Nicole C Berchtold, Victoria Perreau, Journal of neuroinflammation . 2012 ,第3期

机译：微阵列研究：广泛的先天免疫基因激活伴随大脑衰老，增加了对认知能力下降和神经变性的脆弱性
2. THE RELATIONSHIP BETWEEN BRAIN MARKERS OF NEURODEGENERATION AND COGNITION IN PERSONS WITH SUBJECTIVE COGNITIVE DECLINE: A STUDY FROM THE CIMA-Q COHORT [J] . Sylvie Belleville, Carol Hudon, Samira Mellah, Alzheimer’s & dementia: the journal of the Alzheimer’s Association . 2018 ,第7期

机译：主观认知衰退人体脑标志性与认知的关系：CIMA-Q队列的研究
3. Immune activation in brain aging and neurodegeneration: too much or too little? [J] . Lucin KM, Wyss Coray T Neuron . 2009 ,第1期

机译：脑衰老和神经变性中的免疫激活：太多还是太少？
4. Brain Activation and Cognitive Load during EEG Measured Creativity Tasks Accompanied by Relaxation Music [C] . Dalia Papuc, Oana Balan, Maria-Iuliana Dascalu, International Conference on Computer-Human Interaction Research and Applications . 2017

机译：EEG脑激活和认知负荷测量的创造性任务伴随着松弛音乐
5. Mechanisms Regulating Selective Gene Activation During the Innate Immune Response [D] . Tong, Ann-Jay 2015

机译：天然免疫反应过程中调节选择性基因激活的机制
6. PNAS Plus: Dnr1 mutations cause neurodegeneration in Drosophila by activating the innate immune response in the brain [O] . Yang Cao, Stanislava Chtarbanova, Andrew J. Petersen, 2013

机译：PNAS Plus：Dnr1突变通过激活大脑的先天免疫应答而导致果蝇神经变性
7. Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study [O] . 2012

机译：一项微阵列研究显示，广泛的先天免疫基因激活伴随大脑衰老，增加了对认知功能减退和神经变性的脆弱性

Extensive innate immune gene activation accompanies brain aging increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

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