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Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells

机译：阿司匹林触发的脂蛋白A4通过抑制BV-2小胶质细胞中NF-κB和MAPKs的激活来减弱LPS诱导的促炎反应。

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摘要

BackgroundMicroglial activation plays an important role in neurodegenerative diseases through production of nitric oxide (NO) and several pro-inflammatory cytokines. Lipoxins (LXs) and aspirin-triggered LXs (ATLs) are considered to act as 'braking signals' in inflammation. In the present study, we investigated the effect of aspirin-triggered LXA4 (ATL) on infiammatory responses induced by lipopolysaccharide (LPS) in murine microglial BV-2 cells.

机译：背景小胶质细胞激活通过产生一氧化氮（NO）和几种促炎性细胞因子在神经退行性疾病中起重要作用。脂蛋白（LXs）和阿司匹林触发的LX（ATL）被认为是炎症中的“制动信号”。在本研究中，我们调查了阿司匹林触发的LXA4（ATL）对小鼠小胶质BV-2细胞中脂多糖（LPS）诱导的炎症反应的影响。

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期刊名称 Journal of Neuroinflammation
作者
Yan-Ping Wang; Yan Wu; Long-Yan Li; Jin Zheng; Ren-Gang Liu; Jie-Ping Zhou; Shi-Ying Yuan; You Shang; Shang-Long Yao;
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作者单位

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年(卷),期 2011(8),-1
年度 2011
页码 95
总页数 12
原文格式 PDF
正文语种
中图分类神经科学;
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专利

1. Aspirin-triggered lipoxin A₄attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells [J] . Yan-Ping Wang, Yan Wu, Long-Yan Li, Journal of neuroinflammation . 2011,第1期

机译：阿司匹林触发的脂蛋白A _{4 通过抑制BV-2小胶质细胞中NF-κB和MAPKs的激活来减弱LPS诱导的促炎反应。}
2. Aspirin-triggered lipoxin A₄attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells [J] . Yan-Ping Wang, Yan Wu, Long-Yan Li, Journal of neuroinflammation . 2011,第1期

机译：阿司匹林触发的脂蛋白A _{4 通过抑制BV-2小胶质细胞中NF-κB和MAPKs的激活来减弱LPS诱导的促炎反应。}
3. Biochanin?A attenuates LPS-induced pro-inflammatory responses and inhibits the activation of the MAPK pathway in BV2 microglial cells [J] . WuWang-Yang, WuYang-Yang, HuangHuan, International journal of molecular medicine . 2015,第2期

机译：Biochanin？A减弱LPS诱导的促炎反应并抑制BV2小胶质细胞中MAPK途径的激活
4. Betulinic Acid Inhibits Lps-Induced Mmp-9 Expression by Suppressing Nf-Kb Activation in Bv2 Microglial Cells [C] . Sung-Soo Kim International Confernece on Biomedical Engineering in Vietnam . 2013

机译：通过抑制BV2微胶质细胞中的NF-KB活化，桦木酸抑制LPS诱导的MMP-9表达
5. Effects of 1,2,3,4,6 Penta-O-Galloyl-Beta-D-Glucose (PGG) in Activated BV-2 Microglial Cells [D] . Mendonca, Patricia. 2017

机译：1,2,3,4,6 Penta-O-Galloyl-β-D-葡萄糖（PGG）在活性BV-2微胶质细胞中的影响
6. Aspirin-triggered lipoxin A4 attenuates lipopolysaccharide-induced acute lung injury by inhibiting activation of mitogen-activated protein kinases and NF-κB in mice [O] . Mei Liu, Shibiao Chen, You Shang, 2018

机译：阿司匹林触发的脂蛋白A4通过抑制小鼠促细胞分裂素激活的蛋白激酶和NF-κB的激活减轻脂多糖诱导的急性肺损伤
7. Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells [O] . Yan-Ping Wang, Yan Wu, Long-Yan Li, 2011

机译：阿司匹林触发的脂蛋白A4通过抑制BV-2小胶质细胞中NF-κB和MAPKs的激活来减弱LPS诱导的促炎反应。

Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells

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