Different actions of endothelin-1 on chemokine production in rat culturedastrocytes: reduction of CX3CL1/fractalkine and an increase in CCL2/MCP-1 andCXCL1/CINC-1

摘要

BackgroundChemokines are involved in many pathological responses of the brain. Astrocytes produce various chemokines in brain disorders, but little is known about the factors that regulate astrocytic chemokine production. Endothelins (ETs) have been shown to regulate astrocytic functions through ETB receptors. In this study, the effects of ETs on chemokine production were examined in rat cerebral cultured astrocytes.