Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination for subfertility associated with polycystic ovary syndrome

摘要

BackgroundClomiphene citrate (CC) is generally considered first‐line treatment in women with anovulation due to polycystic ovary syndrome (PCOS). Ovulation induction with follicle‐stimulating hormone (FSH; gonadotrophins) is second‐line treatment for women who do not ovulate or conceive while taking CC. Metformin may increase the effectiveness of ovulation induction with gonadotrophins and may promote safety by preventing multiple pregnancy.