Chemokine-mediated inflammation in the degenerating retina is coordinated by Müller cells activated microglia and retinal pigment epithelium

摘要

BackgroundMonocyte infiltration is involved in the pathogenesis of many retinal degenerative conditions. This process traditionally depends on local expression of chemokines, though the roles of many of these in the degenerating retina are unclear. Here, we investigate expression and in situ localization of the broad chemokine response in a light-induced model of retinal degeneration.