Clara Cell Protein (CC16) a Marker of Lung Epithelial Injury Is Decreased in Plasma and Pulmonary Edema Fluid From Patients With Acute Lung Injury

摘要

Background:Acute lung injury (ALI) and ARDS are common clinical syndromes that are underdiagnosed. Clara cell secretory protein (CC16) is an antiinflammatory protein secreted by the Clara cells of the distal respiratory epithelium that has been proposed as a biomarker of lung epithelial injury. We tested the diagnostic and prognostic utility of CC16 in patients with non–trauma-related ALI/ARDS compared to a control group of patients with acute cardiogenic pulmonary edema (CPE).