>Summary: Frozen robust multiarray analysis (fRMA) is a single-array preprocessing algorithm that retains the advantages of multiarray algorithms and removes certain batch effects by downweighting probes that have high between-batch residual variance. Here, we extend the fRMA algorithm to two new microarray platforms—Affymetrix Human Exon and Gene 1.0 ST—by modifying the fRMA probe-level model and extending the frma package to work with oligo ExonFeatureSet and GeneFeatureSet objects.>Availability and implementation: All packages are implemented in R. Source code and binaries are freely available through the Bioconductor project. Convenient links to all software and data packages can be found at >Contact:
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机译：>摘要：冻结鲁棒多阵列分析（fRMA）是一种单阵列预处理算法，它保留了多阵列算法的优势，并通过降低批次间残差高的探针的权重来消除某些批次效应。在这里，我们通过修改fRMA探针级模型并扩展frma包以与oligo ExonFeatureSet和GeneFeatureSet对象一起使用，将fRMA算法扩展到两个新的微阵列平台-Affymetrix Human Exon和Gene 1.0 ST。>可用性和实现： 所有程序包均在R中实现。可通过Bioconductor项目免费获得源代码和二进制文件。可以在>联系方式中找到所有软件和数据包的便捷链接。
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