Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson’s disease

摘要

>See Postuma (doi:) for a scientific commentary on this article. Idiopathic REM sleep behaviour disorder (RBD) is associated with frequent conversion to Parkinson’s disease. Rolinski et al. show that resting-state fMRI differentiates cases of RBD and Parkinson’s disease from controls with high sensitivity (96%) and specificity (74–78%). Basal ganglia network connectivity may reveal future Parkinson’s disease before motor symptom onset.