Facilitation of epileptic activity during sleep is mediated by high amplitude slow waves

摘要

Epileptic discharges are increased during non-REM sleep. By studying the sleep EEG in patients with focal epilepsies, Frauscher et al. show that the increase is specifically associated with high-amplitude slow waves. In contrast to physiological activity, it occurs at transitions from activation to deactivation states, a period of high synchronization.