Long-Term Exposure to Traffic Emissions and Fine Particulate Matter andLung Function Decline in the Framingham Heart Study

摘要

>Rationale: Few studies have examined associations between long-term exposure to fine particulate matter (PM2.5) and lung function decline in adults.>Objectives: To determine if exposure to traffic and PM2.5 is associated with longitudinal changes in lung function in a population-based cohort in the Northeastern United States, where pollution levels are relatively low.>Methods: FEV1 and FVC were measured up to two times between 1995 and 2011 among 6,339 participants of the Framingham Offspring or Third Generation studies. We tested associations between residential proximity to a major roadway and PM2.5 exposure in 2001 (estimated by a land-use model using satellite measurements of aerosol optical thickness) and lung function. We examined differences in average lung function using mixed-effects models and differences in lung function decline using linear regression models. Current smokers were excluded. Models were adjusted for age, sex, height, weight, pack-years, socioeconomic status indicators, cohort, time, season, and weather.>Measurements and Main Results: Living less than 100 m from a major roadway was associated with a 23.2 ml (95% confidence interval [CI], −44.4 to −1.9) lower FEV1 and a 5.0 ml/yr (95% CI, −9.0 to −0.9) faster decline in FEV1 compared with more than 400 m. Each 2 μg/m³ increase in average of PM2.5 was associated witha 13.5 ml (95% CI, −26.6 to −0.3) lower FEV1 and a 2.1 ml/yr(95% CI, −4.1 to −0.2) faster decline in FEV1. There weresimilar associations with FVC. Associations with FEV1/FVC ratio were weakor absent.>Conclusions: Long-term exposure to traffic and PM2.5, atrelatively low levels, was associated with lower FEV1 and FVC and anaccelerated rate of lung function decline.