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Editors choice: High concordance of protein (by IHC) gene (by FISH; HER2 only) and microarray readout (by TargetPrint) of ER PgR and HER2: results from the EORTC 10041/BIG 03-04 MINDACT trial

机译：编辑选择：ERPgR和HER2的蛋白质（通过IHC）基因（通过FISH；仅HER2）和微阵列读数（通过TargetPrint）具有高度一致性：EORTC 10041 / BIG 03-04 MINDACT试验的结果

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BackgroundTo investigate the correlation of TargetPrint with local and central immunohistochemistry/fluorescence in situ hybridization assessment of estrogen (ER), progesterone (PgR), and human epidermal growth factor receptor 2 (HER2) in the first 800 patients enrolled in the MINDACT trial.

机译：背景为了研究TargetPrint与MINDACT试验的前800名患者中雌激素（ER），孕酮（PgR）和人表皮生长因子受体2（HER2）的局部和中央免疫组化/荧光原位杂交评估的相关性。

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期刊名称 Annals of Oncology
作者
G. Viale; L. Slaets; J. Bogaerts; E. Rutgers; L. vant Veer; M. J. Piccart-Gebhart; F. A. de Snoo; L. Stork-Sloots; L. Russo; P. DellOrto; J. van den Akker; A. Glas; F. Cardoso;
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作者单位

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年(卷),期 -1(25),4
年度 -1
页码 816–823
总页数 8
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
breast cancer concordance FISH hormone receptor IHC TargetPrint;

机译：乳腺癌;一致性;FISH;激素受体;IHC;TargetPrint;

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1. High concordance of protein (by IHC), gene (by FISH; HER2 only), and microarray readout (by TargetPrint) of ER, PgR, and HER2: results from the EORTC 10041/BIG 03-04 MINDACT trial. [J] . G Viale, L Slaets, J Bogaerts, Annals of oncology: official journal of the European Society for Medical Oncology . 2014,第4期

机译：ER，PgR和HER2的蛋白质（通过IHC），基因（通过FISH;仅HER2）和微阵列读数（通过TargetPrint）具有高度一致性：EORTC 10041 / BIG 03-04 MINDACT试验的结果。
2. Very low risk of locoregional breast cancer recurrence in the EORTC 10041/BIG 03-04 MINDACT trial: Analysis of risk factors including the 70-gene signature [J] . Rutgers E., Aalders K., Poncet C., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2018,第期

机译：EORTC 10041 / BIG 03-04 Mindact试验中的招生乳腺癌复发的风险非常低：危险因素分析，包括70-基因签名
3. Characterisation of multifocal breast cancer using the 70-gene signature in clinical low-risk patients enrolled in the EORTC 10041/BIG 03-04 MINDACT trial [J] . Aalders K. C., Kuijer A., Straver M. E., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2017,第期

机译：利用70-基因签名在临床低风险患者中征集多焦乳腺癌的鉴别，招聘中临注册041 /大03-04议程试验
4. Comparison of central laboratory assessments of ER PR HER2 and Ki67 by IHC/FISH and the corresponding mRNAs (ESR1 PGR ERBB2 and MKi67) by RT-qPCR on an automated broadly deployed diagnostic platform [O] . Natalie C. Wu, Wendy Wong, Kenneth E. Ho, -1

机译：在广泛部署的自动化诊断平台上通过IHC / FISH对ERPRHER2和Ki67进行中央实验室评估以及通过RT-qPCR对相应的mRNA（ESR1PGRERBB2和MKi67）进行相应的中央实验室评估的比较
5. Discordant assessment of tumor biomarkers by histopathological and molecular assays in the EORTC randomized controlled 10041/BIG 03-04 MINDACT trial breast cancer: Intratumoral heterogeneity and DCIS or normal tissue components are unlikely to be the cause of discordance [O] . Viale, Giuseppe, Dell’Orto, Patrizia P., Glas, Annuska M, 2016

机译：在EORTC随机对照的10041 / BIG 03-04 MINDACT试验乳腺癌中通过组织病理学和分子分析对肿瘤生物标志物进行不一致的评估：肿瘤内异质性和DCIS或正常组织成分不太可能成为不一致的原因

Editors choice: High concordance of protein (by IHC) gene (by FISH; HER2 only) and microarray readout (by TargetPrint) of ER PgR and HER2: results from the EORTC 10041/BIG 03-04 MINDACT trial

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