Helicobacter pylori is a prevalent cause of gastrointestinal infections. Recently, several studies have shown a relationship between H. pylori infection and a variety of extradigestive manifestations. The aim of this study was to review the literature regarding the prevalence of this infection in cases of central serous chorioretinopathy (CSR). We reviewed the EMBASE, Cochrane Library, and Google Scholar search engines; hand-searched many journals; and searched the cited references in published articles for relevant studies. We assessed 81 studies for eligibility. Finally, nine articles that met the inclusion criteria were included. The relationship between H. pylori infection (as the etiologic factor) and chorioretinal involvement was assessed by the effect size with 95% confidence interval (CI). Both fixed- and random-effects models showed that the prevalence of H. pylori infection in patients with CSR was significantly higher than in the control group (2.5-fold and 2.7-fold higher, respectively; P < 0.01). The results were not significantly different between the two models. Treatment of H. pylori infection should be considered in patients with CSR. However, additional randomized controlled clinical trials are required to determine the possible role of H. pylori eradication in the prognosis and treatment of patients with CSR.
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机译：幽门螺杆菌是胃肠道感染的普遍原因。最近，一些研究表明幽门螺杆菌感染与多种消化不良表现之间的关系。这项研究的目的是回顾有关中枢性浆液性脉络膜视网膜病变（CSR）病例中这种感染发生率的文献。我们审查了EMBASE，Cochrane库和Google Scholar搜索引擎；手工搜索许多期刊；并在已发表文章中引用的参考文献进行了相关研究。我们评估了81项研究的资格。最后，包括符合纳入标准的九篇文章。幽门螺杆菌感染（作为病因）与脉络膜视网膜受累之间的关系通过效应大小（95％置信区间（CI））进行评估。固定效应模型和随机效应模型均显示，CSR患者的幽门螺杆菌感染率明显高于对照组（分别高2.5倍和2.7倍； P <0.01）。两个模型之间的结果没有显着差异。 CSR患者应考虑治疗幽门螺杆菌感染。但是，还需要其他随机对照临床试验来确定根除幽门螺杆菌在CSR患者的预后和治疗中的可能作用。
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