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Phosphoinositide interacting regulator of TRP (Pirt) enhances TRPM8 channel activity in vitro via increasing channel conductance

机译：磷酸肌醇相互作用的TRP调节剂（Pirt）通过增加通道电导来增强TRPM8通道的体外活性

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摘要

Aim:Pirt is a two-transmembrane domain protein that regulates the function of a variety of ion channels. Our previous study indicated that Pirt acts as a positive endogenous regulator of the TRPM8 channel. The aim of this study was to investigate the mechanism underlying the regulation of TRPM8 channel by Pirt.

机译：目的：Pirt是一种跨膜结构域蛋白，可调节多种离子通道的功能。我们之前的研究表明，Pirt充当TRPM8通道的正内源调节剂。这项研究的目的是研究Pirt调节TRPM8通道的潜在机制。

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期刊名称 Acta Pharmacologica Sinica
作者
Min Tang; Guang-yi Wu; Xin-zhong Dong; Zong-xiang Tang;
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作者单位

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年(卷),期 2016(37),1
年度 2016
页码 98–104
总页数 7
原文格式 PDF
正文语种
中图分类药学;
关键词
TRPM8 menthol Pirt PIP2 PI whole-cell recording single channel conductance;

机译：TRPM8;薄荷醇;Pirt;PIP2;PI;全细胞记录;单通道电导;

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专利

1. Phosphoinositide interacting regulator of TRP (Pirt) enhances TRPM8 channel activity in vitro via increasing channel conductance [J] . Min TANG, Guang-yi WU, Xin-zhong DONG, 中国药理学报：英文版 . 2016,第001期

机译：磷酸肌醇相互作用的TRP调节剂（Pirt）通过增加通道电导来增强TRPM8通道的体外活性
2. Effect of Activation of Peripheral Ion Channel TRPM8 on Gene Expression of Thermosensitive TRP Ion Channels in the Hypothalamus. Comparison with the Effect of Cooling [J] . Kozyreva T. V., Evtushenko A. A., Voronova I. P., Bulletin of experimental biology and medicine . 2018,第2期

机译：外周离子通道Trpm8对丘脑中热敏Trp离子通道基因表达的影响。比较冷却效果
3. Competitive Interactions between PIRT, the Cold Sensing Ion Channel TRPM8, and PIP2 Suggest a Mechanism for Regulation [J] . Nicholas J. Sisco, Cole V. M. Helsell, Wade D. Van Horn Scientific reports. . 2019,第1期

机译：PIRT之间的竞争相互作用，冷却离子通道TRPM8和PIP2建议了调节机制
4. Role of TRP channels in endothelialpathophysiology-evidence for vascular TRPs as apotential target for drug therapy [C] . Annarita Graziani, Michael Poteser, Christian Rosker, International Symposium on Atherosclerosis . 2004

机译：TRP通道在内皮病理学生理学中的作用 - 血管TRP的证据作为药物治疗的潜在目标
5. Phosphoinositide interacting regulator of TRP (Pirt), a novel membrane protein in the somatosensory system. [D] . Kim, Andrew Yong Chae. 2009

机译：磷酸肌醇相互作用调节剂TRP（Pirt），一种在体感系统中的新型膜蛋白。
6. Phosphoinositide-interacting regulator of TRP (PIRT) has opposing effects on human and mouse TRPM8 ion channels [O] . Jacob K. Hilton, Taraneh Salehpour, Nicholas J. Sisco, 2018

机译：磷酸肌醇与TRP的相互作用调节剂（PIRT）对人和小鼠的TRPM8离子通道具有相反的作用
7. Phosphoinositide-interacting regulator of TRP (PIRT) has opposing effects on human and mouse TRPM8 ion channels [O] . Jacob K. Hilton, Taraneh Salehpour, Nicholas J. Sisco, 2018

机译：TRP（PIRT）的磷酸阳肌酸阳性稳压剂对人和小鼠TRPM8离子通道的反对作用

Phosphoinositide interacting regulator of TRP (Pirt) enhances TRPM8 channel activity in vitro via increasing channel conductance

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