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The PPARγ agonist rosiglitazone attenuates airway inflammation and remodeling via heme oxygenase-1 in murine model of asthma

机译：PPARγ激动剂罗格列酮可通过血红素加氧酶-1减轻哮喘小鼠模型的气道炎症和重塑

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摘要

Aim:Rosiglitazone is one of the specific PPARγ agonists showing potential therapeutic effects in asthma. Though PPARγ activation was considered protective in inhibiting airway inflammation and remodeling in asthma, the specific mechanisms are still unclear. This study was aimed to investigate whether heme oxygenase-1 (HO-1) related pathways were involved in rosiglitazone-activated PPARγ signaling in asthma treatment.

机译：目的：罗格列酮是特异性PPARγ激动剂之一，对哮喘具有潜在的治疗作用。尽管PPARγ激活被认为可以抑制哮喘的气道炎症和重塑，但具体机制仍不清楚。本研究旨在探讨在哮喘治疗中，罗格列酮激活的PPARγ信号传导是否涉及血红素加氧酶-1（HO-1）相关途径。

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期刊名称 Acta Pharmacologica Sinica
作者
Jing Xu; Yan-ting Zhu; Gui-zuo Wang; Dong Han; Yuan-yuan Wu; De-xin Zhang; Yun Liu; Yong-hong Zhang; Xin-ming Xie; Shao-jun Li; Jia-mei Lu; Lu Liu; Wei Feng; Xiu-zhen Sun; Man-xiang Li;
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年(卷),期 2015(36),2
年度 2015
页码 171–178
总页数 8
原文格式 PDF
正文语种
中图分类药学;
关键词
asthma OVA-induced asthma PPARγ rosiglitazone HO-1 p21 MMP-2 MMP-9 ZnPP;

机译：哮喘;OVA诱发的哮喘;PPARγ;罗格列酮;HO-1;p21;MMP-2;MMP-9;ZnPP;

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专利

1. The PPARγ agonist, rosiglitazone, attenuates airway inflammation and remodeling via heme oxygenase-1 in murine model of asthma [J] . Jing XU, Yan-ting ZHU, Gui-zuo WANG, 中国药理学报：英文版 . 2015,第002期

机译：PPARγ激动剂罗格列酮可通过血红素加氧酶-1减轻哮喘小鼠模型中的气道炎症和重塑
2. Rosiglitazone, a peroxisome proliferator-activated receptor-γ agonist, attenuates airway inflammation by inhibiting the proliferation of effector T cells in a murine model of neutrophilic asthma [J] . ZhaoY., HuangY., HeJ., Immunology Letters . 2014,第1a2期

机译：罗格列酮，一种过氧化物酶体增殖物激活的受体-γ激动剂，通过抑制中性粒细胞性哮喘小鼠模型中效应T细胞的增殖来减轻气道炎症
3. PPAR Agonist PGZ Attenuates OVA-Induced Airway Inflammation and Airway Remodeling via RGS4 Signaling in Mouse Model [J] . Meng Xia, Sun Xinrong, Zhang Yonghong, Inflammation . 2018,第6期

机译：PPAR激动剂PGZ通过RGS4信号传导在小鼠模型中衰减OVA诱导的气道炎症和气道重塑
4. Effects of Over Expression of LTC4 Synthase Gene on Development of Th2 Type Airway Inflammation in Murine Model of Bronchial Asthma [C] . K. Honda, M. Arima, G. Cheng Asia Pacific Congress of Allergology and Clinical Immunology . 2004

机译：LTC4合成酶基因表达对支气管哮喘鼠模型Th2型气道炎症发育的影响
5. Attenuation of airway hyperreactivity by gram- negative lipopolysaccharide in a murine model of asthma. [D] . Jackson-Humbles, Daven. 2014

机译：革兰氏阴性脂多糖在哮喘小鼠模型中减轻气道高反应性。
6. Effect of intranasal rosiglitazone on airway inflammation and remodeling in a murine model of chronic asthma [O] . Hwa Young Lee, Chin Kook Rhee, Ji Young Kang, 2016

机译：鼻内罗格列酮对慢性哮喘小鼠模型气道炎症和重塑的影响
7. The PPARγ agonist, rosiglitazone, attenuates airway inflammation and remodeling via heme oxygenase-1 in murine model of asthma [O] . Jing Xu, Yan-ting Zhu, Gui-zuo Wang, 2015

机译：PPARγ激动剂，Rosiglitazone，通过哮喘小鼠模型中通过血红素氧合酶-1衰减气道炎症和重塑

The PPARγ agonist rosiglitazone attenuates airway inflammation and remodeling via heme oxygenase-1 in murine model of asthma

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