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Inhibition of Hec1 expression enhances the sensitivity of human ovarian cancer cells to paclitaxel

机译：抑制Hec1表达可增强人类卵巢癌细胞对紫杉醇的敏感性

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摘要

Aim:Hec1, a member of the Ndc80 kinetochore complex, is highly expressed in cancers. The aim of this study was to explore the role and mechanism of action of Hec1 with respect to the cytotoxicity of paclitaxel in ovarian cancer.

机译：目的：Hec1是Ndc80线粒体复合体的成员，在癌症中高度表达。这项研究的目的是探讨紫杉醇在卵巢癌中对Hec1的细胞毒性作用和作用机理。

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期刊名称 Acta Pharmacologica Sinica
作者
Qing-qing Mo; Ping-bo Chen; Xin Jin; Qian Chen; Lan Tang; Bei-bei Wang; Ke-zhen Li; Peng Wu; Yong Fang; Shi-xuan Wang; Jian-feng Zhou; Ding Ma; Gang Chen;
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作者单位

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年(卷),期 2013(34),4
年度 2013
页码 541–548
总页数 8
原文格式 PDF
正文语种
中图分类药学;
关键词
Hec1 ovarian cancer paclitaxel siRNA mitotic checkpoint apoptosis cell cycle;

机译：Hec1;卵巢癌;紫杉醇;siRNA;有丝分裂检查点;凋亡;细胞周期;

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专利

1. Inhibition of Hec1 expression enhances the sensitivity of human ovarian cancer cells to paclitaxel [J] . Qing-qing MO, Ping-bo CHEN, Xin JIN, 中国药理学报：英文版 . 2013,第004期

机译：抑制Hec1表达可增强人类卵巢癌细胞对紫杉醇的敏感性
2. miR-21 modulates paclitaxel sensitivity and hypoxia-inducible factor-1α expression in human ovarian cancer cells [J] . XieZ., CaoL., ZhangJ. Oncology letters . 2013,第3期

机译：miR-21调节紫杉醇敏感性和缺氧诱导因子-1α在人卵巢癌细胞中的表达
3. ings identical to those of the primary tumor. Chemosensitivity test showed that paclitaxel induced the highest chemosensitivity index. In microarray analysis, 2,520 probes were differently expressed, compared to human ovarian surface epithelial cells (HOSEs). In SYBR Green real-time PCR, the expression of E2F2 (P = 0.040) and CRABP2 genes (P = 0.030) was significantly higher in the ovarian cancer cell lines than in HOSEs. Furthermore, proteomic analysis showed that expression of 28 spots was sig [J] . Diabetes/metabolism research and reviews . 2009,第6期

机译：与原发肿瘤相同。化学敏感性试验表明紫杉醇诱导了最高的化学敏感性指数。在微阵列分析中，与人卵巢表面上皮细胞（HOSE）相比，表达了2520个探针。在SYBR Green实时PCR中，卵巢癌细胞系中E2F2（P = 0.040）和CRABP2基因（P = 0.030）的表达明显高于HOSE。此外，蛋白质组学分析显示28个斑点的信号
4. Akt Involvement in Paclitaxel Chemoresistance of Human Ovarian Cancer Cells [C] . SU-HYEONG KIM, YONG-SUNG JUHNN, YONG-SANG SONG Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：Akt参与人类卵巢癌细胞紫杉醇的耐药性
5. Mechanism of paclitaxel-induced IL-8 expression in human ovarian cancer cells: Molecular biology and clinical therapy. [D] . Lee, Li-Fen. 1998

机译：紫杉醇诱导人卵巢癌细胞中IL-8表达的机制：分子生物学和临床治疗。
6. Targeted inhibition of phosphatidyl inositol-3-kinase p110β but not p110α enhances apoptosis and sensitivity to paclitaxel in chemoresistant ovarian cancers [O] . Ju-yeon Jeong, Kyung-Sul Kim, Ji-Sook Moon, -1

机译：靶向抑制磷脂酰肌醇3激酶p110β而不是p110α可以增强化疗耐药性卵巢癌的凋亡和对紫杉醇的敏感性
7. Inhibition of Hec1 expression enhances the sensitivity of human ovarian cancer cells to paclitaxel [O] . Qing-qing Mo, Ping-bo Chen, Xin Jin, 2013

机译：HEC1表达的抑制增强了人卵巢癌细胞对紫杉醇的敏感性
8. Effect of Protein Kinase C Modulation with Bryostatin 1 on Paclitaxel-Induced Growth Inhibition and Apoptosis in Human Breast Cancer Cell Lines [R] . Hahm, H. A. 1999

机译：蛋白激酶C调节苔藓抑素1对紫杉醇诱导的人乳腺癌细胞生长抑制和凋亡的影响

Inhibition of Hec1 expression enhances the sensitivity of human ovarian cancer cells to paclitaxel

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