Phytochemical screening was carried out on the ethylacetate portion of the ethanolic extract of the leaves of Pseudocedrella kotschyii and then evaluated for its analgesic (acetic acid-induced writhing) and anti-inflammatory (raw egg albumin-induced oedema) activities in mice and rats respectively. Phytochemical screening of the ethylacetate partition portion of ethanolic extract revealed the presence of flavonoids, glycosides and tannins as major chemical constituents. Alkaloids saponins, cardiac glycosides, steroids were not dictated in the extract. The ethylacetate extract (50 and 100 mg/kg i.p) exhibited significant activity (p<0.05) against acetic acid-induced writhing in a dose dependent manner. In the anti-inflammatory activity the ethylacetate extract (50 and 100 mg/kg i.p.) caused a slight effect against the raw egg albumin-induced oedema. The effect was however observed not to be dose dependent. All these effects were compared with standard drug piroxicam (20 mg/kg i.p.).
展开▼
机译:对科氏假单胞菌叶的乙醇提取物的乙酸乙酯部分进行植物化学筛选,然后分别评估其在小鼠和大鼠中的镇痛作用(乙酸引起的扭结)和抗炎作用(生卵白蛋白引起的水肿)活性。 。对乙醇提取物的乙酸乙酯分配部分进行植物化学筛选后,发现黄酮类,糖苷和丹宁酸为主要化学成分。提取物中未规定生物碱皂苷,强心苷,类固醇。乙酸乙酯提取物(50和100 mg / kg i.p)以剂量依赖性方式表现出显着的抗乙酸诱导扭体活性(p <0.05)。在抗炎活性方面,乙酸乙酯提取物(50和100 mg / kg i.p.)对生鸡蛋白蛋白引起的水肿产生轻微影响。然而,观察到该作用不是剂量依赖性的。将所有这些作用与标准药物吡罗昔康(20 mg / kg腹腔注射)进行比较。
展开▼