Dose omission to shorten methacholine challenge testing: clinical consequences of the use of a 10 fall in FEV1 threshold

摘要

IntroductionIn methacholine challenge testing (MCT), skipping a methacholine dose is suggested if FEV1 falls by < 5%. Using a larger threshold may further shorten test duration, but data supporting this hypothesis is lacking. We evaluated the safety and consequences of using a 10% FEV1 fall as threshold to skip the next dose of methacholine in patients undergoing MCT.