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Deep Learning Meets Biomedical Ontologies: Knowledge Embeddings for Epilepsy

机译:深度学习遇到生物医学本体论:癫痫病的知识嵌入

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摘要

While biomedical ontologies have traditionally been used to guide the identification of concepts or relations in biomedical data, recent advances in deep learning are able to capture high-quality knowledge from textual data and represent it in graphical structures. As opposed to the top-down methodology used in the generation of ontologies, which starts with the principled design of the upper ontology, the bottom-up methodology enabled by deep learning encodes the likelihood that concepts share certain relations, as evidenced by data. In this paper, we present a knowledge representation produced by deep learning methods, called Medical Knowledge Embeddings (MKE), that encode medical concepts related to the study of epilepsy and the relations between them. Many of the epilepsy-relevant medical concepts from MKE are not yet available in existing biomedical ontologies, but are mentioned in vast collections of epilepsy-related medical records which also imply their relationships. The evaluation of the MKE indicates high accuracy of the medical concepts automatically identified from clinical text as well as promising results in terms of correctness and completeness of relations produced by deep learning.
机译:尽管传统上一直使用生物医学本体论来指导生物医学数据中概念或关系的识别,但深度学习的最新进展仍能够从文本数据中捕获高质量的知识,并将其以图形结构表示。与本体生成中使用的自上而下的方法(从上层本体的原则设计开始)相反,深度学习支持的自下而上的方法编码了概念共享某些关系的可能性,如数据所示。在本文中,我们介绍了一种由深度学习方法产生的知识表示,称为医学知识嵌入(MKE),该知识表示对与癫痫研究及其之间的关系有关的医学概念进行了编码。 MKE的许多与癫痫相关的医学概念尚未在现有的生物医学本体中提供,但在大量与癫痫相关的医学记录中被提及,这也暗示了它们之间的关系。对MKE的评估表明,从临床文本中自动识别出的医学概念具有很高的准确性,并且在深度学习产生的关系的正确性和完整性方面具有可喜的结果。

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