Using Computers to Survey the Epidemiological Environmental and Genetic Factors Involved in the Process of Bacteria Resistance Acquisition

摘要

The sensitivity behavior in time of several species (S.aureus, E.coli, K.pneumoniae and P.mirabilis in a total of 16334 positive cultures collected at our hospital from July 1981 to December 1986) to amikacin and gentamicin are shown to be periodic. The implications of this finding, and parameters, both epidemiological and genetic, that might be of relevance in its understanding, are discussed as being necessary characteristics of a nosocomial survey-and-control computer system in which time-series analysis techniques are of central importance.