AB106. The role of apolipoprotein E polymorphism in dyslipidemic obese adolescents who received the intervention of physical exercise and National Cholesterol Education Program step II

摘要

Background and objectiveLifestyle changes including physical exercise and diet is the management of dyslipidemia before considering the blood lipid-lowering drugs. Genetics factor is often regarded as the cause of the management’s failure in dyslipidemic subjects who had been doing physical exercise obediently and good diet consumption. This article aims: (I) to create the algorithms of dyslipidemia management in obese adolescents including apolipoprotein (apo) E polymorphism with 28 days of physical exercise and National Cholesterol Education Program (NCEP) step II diet interventions in order to start giving the blood-lipid lowering drugs; (II) To determine the apo E genotype’s profiles in subjects who has improved and unimproved lipid profile levels; and (III) To determine the apo E alleles’ roles in improving the lipid profile levels.