Contribution of vraSR and graSR Point Mutations to Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus

机译：vraSR和graSR点突变对万古霉素中间金黄色葡萄球菌对万古霉素耐药性的贡献

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摘要

We describe here the genetic analysis of a vancomycin-susceptible Staphylococcus aureus (VSSA) strain, Mu50Ω, a strain related to vancomycin-intermediate S. aureus (VISA) strain Mu50. Using a combination of Mu50Ω whole-genome sequencing and genome engineering, we observed a stepwise evolution of vancomycin resistance from VSSA to VISA after the mutated vraS and graR genes of Mu50 were engineered into Mu50Ω.

机译：我们在这里描述了对万古霉素敏感的金黄色葡萄球菌（VSSA）菌株Mu50Ω的遗传分析，该菌株与万古霉素中间金黄色葡萄球菌（VISA）菌株Mu50有关。通过将Mu50Ω全基因组测序和基因组工程相结合，我们观察到将Mu50的突变vraS和graR基因改造为Mu50Ω后，从VSSA到VISA的万古霉素抗性逐步演变。

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期刊名称 Antimicrobial Agents and Chemotherapy
作者
Longzhu Cui; Hui-min Neoh; Mitsutaka Shoji; Keiichi Hiramatsu;
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作者单位

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年(卷),期 2009(53),3
年度 2009
页码 1231–1234
总页数 4
原文格式 PDF
正文语种
中图分类药学;微生物学;
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专利

1. Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. [J] . Cui L, Neoh HM, Shoji M Antimicrobial agents and chemotherapy. . 2009,第3期

机译：vraSR和graSR点突变对万古霉素中间金黄色葡萄球菌对万古霉素耐药的贡献。
2. Contribution of selected gene mutations to resistance in clinical isolates of vancomycin-intermediate staphylococcus aureus [J] . HaferC., LinY., KornblumJ., Antimicrobial agents and chemotherapy. . 2012,第11期

机译：选定的基因突变对万古霉素中间金黄色葡萄球菌临床分离株耐药性的贡献
3. Contribution of selected gene mutations to resistance in clinical isolates of vancomycin-intermediate staphylococcus aureus [J] . HaferC., LinY., KornblumJ., Antimicrobial agents and chemotherapy. . 2012,第11期

机译：选定的基因突变对万古霉素中间金黄色葡萄球菌临床分离株耐药性的贡献
4. Synergistic Antibacterial Activities of Bioactive Compounds from Streptomyces sp. RS2 in Combination with Vancomycin against Staphylococcus aureus [C] . Nongyao Nonpanya, Suwanna Niamsanit, Kwanjai Kanokmedhakul, IEEE International Conference on Engineering Technologies and Applied Sciences . 2018

机译：链霉菌属生物活性化合物的协同抗菌活性。 RS2联合万古霉素抗金黄色葡萄球菌
5. Cloning and purification of the two component system GraSR involved in glycopeptide antibiotic resistance in Staphylococcus aureus (Mu50), and characterization of the citrate/methylcitrate synthase from Bacillus subtilis strain 168. [D] . Onyemachi, Jeremiah. 2011

机译：克隆和纯化金黄色葡萄球菌（Mu50）中涉及糖肽抗生素耐药性的两组分系统GraSR，并表征了枯草芽孢杆菌菌株168的柠檬酸/甲基柠檬酸合酶。
6. Contribution of Selected Gene Mutations to Resistance in Clinical Isolates of Vancomycin-Intermediate Staphylococcus aureus [O] . Cory Hafer, Ying Lin, John Kornblum, 2012

机译：所选基因突变对万古霉素中间金黄色葡萄球菌临床分离株耐药性的贡献
7. Contribution of vraSR and graSR Point Mutations to Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus▿ [O] . Cui, Longzhu, Neoh, Hui-min, Shoji, Mitsutaka, 2009

机译：vraSR和graSR点突变对万古霉素中间金黄色葡萄球菌对万古霉素耐药的贡献
8. Guideline for the Prevention and Management of Methicillin-Resistant Staphylococcus aureus (MRSA), Vancomycin-Resistant Enterococcus (VRE), and Vancomycin-Intermediate/Resistant Staphyloccocus aureus (VISA/VRSA) in Indiana Health Care [R] . 2004

机译：印第安纳州医疗保健中预防和管理耐甲氧西林金黄色葡萄球菌（mRsa），耐万古霉素肠球菌（VRE）和万古霉素中间/抗性金黄色葡萄球菌（VIsa / VRsa）的指南

Contribution of vraSR and graSR Point Mutations to Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus

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