Mutant Prevention Concentrations of Levofloxacin Alone and in Combination with Azithromycin Ceftazidime Colistin (Polymyxin E) Meropenem Piperacillin-Tazobactam and Tobramycin against Pseudomonas aeruginosa

摘要

The mutant prevention concentrations (MPCs) of levofloxacin alone and in combination with ceftazidime, colistin (polymyxin E), meropenem, piperacillin-tazobactam, and tobramycin were established against Pseudomonas aeruginosa. Antibiotic combinations using levofloxacin with any antibiotic with individual activity against P. aeruginosa resulted in synergistic lowering (an at-least-fourfold reduction) of the isolate's MPC.