Nebulised antibiotics have been shown to be beneficial in the treatment of lung infections in cystic fibrosis. Studies on the efficiency of nebuliser systems are constantly required in view of the large number of compressor/drugebuliser combinations which are possible and the development of new systems and drugs. Six combinations of three commercially available compressors were compared (PortaNeb 50 (Medic-Aid; 5.4-6.1 l/min), Turboneb (Medix; 8.3-9.1 l/min), and CR 60 (Medic-Aid; 7.3-7.8 l/min)) and two jet nebulisers (Microneb III (Lifecare) and System 22 Acorn (Medic-Aid)) for the nebulisation of colomycin, gentamicin, and ciprofloxacin. Aerosol droplet size, nebulisation time, and aerosol output were determined. Turboneb and CR 60 reduced the nebulisation time and produced higher proportions of 'respirable' (< 5 microns diameter) antibiotic aerosols. The residual volume of the Microneb III was lower than that of the System 22 Acorn. It was found that the Turboneb and CR 60, when coupled with either Microneb III or System 22 Acorn, were suitable for the nebulisation of all three antibiotics. Of the equipment tested, Turboneb coupled with Microneb III was the most efficient combination. Even with this combination, only around 50% of the nominal dose was released as respirable aerosol.
展开▼
机译:雾化抗生素已被证明对治疗囊性纤维化的肺部感染有益。鉴于可能存在的大量压缩机/药物/雾化器组合以及新系统和药物的开发,一直需要对喷雾器系统的效率进行研究。比较了三种市售压缩机的六种组合(PortaNeb 50(Medic-Aid; 5.4-6.1 l / min),Turboneb(Medix; 8.3-9.1 l / min)和CR 60(Medic-Aid; 7.3-7.8 l / min)分钟))和两个喷射雾化器(Microneb III(Lifecare)和System 22 Acorn(Medic-Aid))用于雾化霉素,庆大霉素和环丙沙星。确定气雾滴尺寸,雾化时间和气雾输出。 Turboneb和CR 60减少了雾化时间,并产生了更高比例的“可吸入”(直径小于5微米)抗生素气雾剂。 Microneb III的残留量低于System 22 Acorn的残留量。发现Turboneb和CR 60与Microneb III或System 22 Acorn结合使用时,适用于所有三种抗生素的雾化。在测试的设备中,Turboneb与Microneb III结合是最有效的组合。即使采用这种组合,也仅释放了约50%的标称剂量的可吸入气雾剂。
展开▼