Radiosynthesis of 11C-phenytoin Using a DEGDEE Solvent for Clinical PET Studies

摘要

Objective(s):Phenytoin is an antiepileptic drug that is used worldwide. The whole-body pharmacokinetics of this drug have been extensively studied using ¹¹C-phenytoin in small animals. However, because of the limited production amounts that are presently available, clinical ¹¹C-phenytoin PET studies to examine the pharmacokinetics of phenytoin in humans have not yet been performed. We aimed to establish a new synthesis method to produce large amounts of ¹¹C-phenytoin to conduct human studies.