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Terahertz identification and quantification of neurotransmitter and neurotrophy mixture

机译:太赫兹对神经递质和神经营养混合物的鉴定和定量

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摘要

Terahertz spectroscopy has been widely used for investigating the fingerprint spectrum of different substances. For cancerous tissues, the greatest difficulty is the absorption peaks of various substances contained in tissues overlap with each other, which are hard to identify and quantitative analyze. As a result, it is very hard to measure the presence of cancer cell and then to diagnose accurately. In this paper, we select three typical neurotransmitters (γ-aminobutyric acid, L-glutamic acid, dopamine hydrochloride) and two typical metabolites (inositol and creatine) in neurons to measure their terahertz spectra with different mixture ratios. By choosing characteristic absorption peaks, removing baseline and using the least square method, we can identify the components and proportions of each mixture, where the goodness of fit to practical situation is up to 94%. These results provide important evidences for identifying nerve substances and obtaining exact quantitative analysis.
机译:太赫兹光谱已被广泛用于研究不同物质的指纹图谱。对于癌组织,最大的困难是组织中所含的各种物质的吸收峰相互重叠,难以识别和定量分析。结果,很难测量癌细胞的存在然后准确地诊断。在本文中,我们选择了神经元中的三种典型神经递质(γ-氨基丁酸,L-谷氨酸,盐酸多巴胺)和两种典型代谢物(肌醇和肌酸)来测量它们在不同混合比下的太赫兹光谱。通过选择特征吸收峰,去除基线并使用最小二乘法,我们可以确定每种混合物的成分和比例,其中符合实际情况的良率高达94%。这些结果为鉴定神经物质和获得准确的定量分析提供了重要的证据。

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