Model-driven intracellular redox status modulation for increasing isobutanol production in Escherichia coli

摘要

BackgroundFew strains have been found to produce isobutanol naturally. For building a high performance isobutanol-producing strain, rebalancing redox status of the cell was very crucial through systematic investigation of redox cofactors metabolism. Then, the metabolic model provided a powerful tool for the rational modulation of the redox status.