Genome-scale reconstruction of the sigma factor network in Escherichia coli: topology and functional states

摘要

BackgroundAt the beginning of the transcription process, the RNA polymerase (RNAP) core enzyme requires a σ-factor to recognize the genomic location at which the process initiates. Although the crucial role of σ-factors has long been appreciated and characterized for many individual promoters, we do not yet have a genome-scale assessment of their function.