Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG) Irgm1 causes activation of effector IRG proteins on lysosomes damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection

摘要

BackgroundThe interferon-γ (IFN-γ)-inducible immunity-related GTPase (IRG), Irgm1, plays an essential role in restraining activation of the IRG pathogen resistance system. However, the loss of Irgm1 in mice also causes a dramatic but unexplained susceptibility phenotype upon infection with a variety of pathogens, including many not normally controlled by the IRG system. This phenotype is associated with lymphopenia, hemopoietic collapse, and death of the mouse.