Collagen matrices from sponge to nano: new perspectives for tissue engineering of skeletal muscle

摘要

BackgroundTissue engineering of vascularised skeletal muscle is a promising method for the treatment of soft tissue defects in reconstructive surgery. In this study we explored the characteristics of novel collagen and fibrin matrices for skeletal muscle tissue engineering. We analyzed the characteristics of newly developed hybrid collagen-I-fibrin-gels and collagen nanofibers as well as collagen sponges and OPLA^®-scaffolds. Collagen-fibrin gels were also tested with genipin as stabilizing substitute for aprotinin.