Evaluation of public cancer datasets and signatures identifies TP53 mutant signatures with robust prognostic and predictive value

摘要

BackgroundSystematic analysis of cancer gene-expression patterns using high-throughput transcriptional profiling technologies has led to the discovery and publication of hundreds of gene-expression signatures. However, few public signature values have been cross-validated over multiple studies for the prediction of cancer prognosis and chemosensitivity in the neoadjuvant setting.