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Phase I trial of split-dose induction docetaxel cisplatin and 5-fluorouracil (TPF) chemotherapy followed by curative surgery combined with postoperative radiotherapy in patients with locally advanced oral and oropharyngeal squamous cell cancer (TISOC-1)

机译：局部晚期口腔和口咽鳞状细胞癌（TISOC-1）患者的分剂量诱导多西他赛顺铂和5-氟尿嘧啶（TPF）化疗+根治性手术联合术后放疗的I期试验

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BackgroundInduction chemotherapy (ICT) with docetaxel, cisplatin and fluorouracil (TPF) followed by radiotherapy is an effective treatment option for unresectable locally advanced head and neck cancer. This phase I study was designed to investigate the safety and tolerability of a split-dose TPF ICT regimen prior to surgery for locally advanced resectable oral and oropharyngeal cancer.

机译：背景采用多西他赛，顺铂和氟尿嘧啶（TPF）的诱导化疗（ICT）继之以放射疗法，是无法切除的局部晚期头颈癌的有效治疗选择。 I期研究旨在研究局部晚期可切除口腔和口咽癌手术前分剂量TPF ICT方案的安全性和耐受性。

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期刊名称 BMC Cancer
作者
Katrin Oertel; Karin Spiegel; Harald Schmalenberg; Andreas Dietz; Georg Maschmeyer; Thomas Kuhnt; Holger Sudhoff; Thomas G Wendt; Orlando Guntinas-Lichius;
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作者单位

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年(卷),期 2012(12),-1
年度 2012
页码 483
总页数 9
原文格式 PDF
正文语种
中图分类肿瘤学 ;
关键词
Docetaxel Cisplatin 5-fluorouracil Locally advanced oral cancer Surgery Radiotherapy;

机译：多西他赛;顺铂;5-氟尿嘧啶;局部晚期口腔癌;手术;放疗;

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专利

1. A two-arm multicenter phase II trial of one cycle chemoselection split-dose docetaxel, cisplatin and 5-fluorouracil (TPF) induction chemotherapy before two cycles of split TPF followed by curative surgery combined with postoperative radiotherapy in patients with locally advanced oral and oropharyngeal squamous cell cancer (TISOC-1) [J] . Inhestern J., Schmalenberg H., Dietz A., Annals of oncology: official journal of the European Society for Medical Oncology . 2017 ,第8期

机译：双臂多中心第二期试验的一个循环化学选择分裂剂DODETAXEL，顺铂和5-氟尿嘧啶（TPF）诱导化疗，在分裂TPF的两个循环之前，疗法手术与局部晚期口服和口咽鳞状的术后放射治疗联合细胞癌（Tisoc-1）
2. Phase I trial of split-dose induction docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy followed by curative surgery combined with postoperative radiotherapy in patients with locally advanced oral and oropharyngeal squamous cell cancer (TISOC-1) [J] . Katrin Oertel, Karin Spiegel, Harald Schmalenberg, BMC Cancer . 2012 ,第1期

机译：局部晚期口腔和口咽鳞状细胞癌（TISOC-1）患者的分剂量诱导多西他赛，顺铂和5-氟尿嘧啶（TPF）化疗联合治愈性手术与术后放疗的I期试验
3. Phase I trial of split-dose induction docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy followed by curative surgery combined with postoperative radiotherapy in patients with locally advanced oral and oropharyngeal squamous cell cancer (TISOC-1) [J] . Katrin Oertel, Karin Spiegel, Harald Schmalenberg, BMC Cancer . 2012 ,第1期

机译：局部晚期口腔和口咽鳞状细胞癌（TISOC-1）患者的分剂量诱导多西他赛，顺铂和5-氟尿嘧啶（TPF）化疗联合治愈性手术与术后放疗的I期试验
4. Pemetrexed versus docetaxel single agent chemotherapy in chemotherapy-naive elderly patients with advanced non-small cell lung cancer [C] . Hua Xin, Zhenguo Han, Haibo Huang 2011 International Conference on Human Health and Biomedical Engineering . 2011

机译：培美曲塞与多西他赛单药化疗在未接受化疗的老年晚期非小细胞肺癌患者中的作用
5. Prognostic Role of Circulating Tumor Cells during Induction Chemotherapy Followed by Curative Surgery Combined with Postoperative Radiotherapy in Patients with Locally Advanced Oral and Oropharyngeal Squamous Cell Cancer [O] . Johanna Inhestern, Katrin Oertel, Viola Stemmann, -1

机译：局部晚期口腔和口咽鳞状细胞癌患者诱导化疗后根治性手术联合术后放疗后循环肿瘤细胞的预后作用
6. Phase I trial of split-dose induction docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy followed by curative surgery combined with postoperative radiotherapy in patients with locally advanced oral and oropharyngeal squamous cell cancer (TISOC-1) [O] . 2012

机译：局部晚期口腔和口咽鳞状细胞癌（TISOC-1）患者的分剂量诱导多西他赛，顺铂和5-氟尿嘧啶（TPF）化疗联合治愈性手术和术后放疗的I期试验

Phase I trial of split-dose induction docetaxel cisplatin and 5-fluorouracil (TPF) chemotherapy followed by curative surgery combined with postoperative radiotherapy in patients with locally advanced oral and oropharyngeal squamous cell cancer (TISOC-1)

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