Secondary metabolites from the Aspergillus sp. in the rhizosphere soil of Phoenix dactylifera (Palm tree)

摘要

The soil-derived fungus Aspergillus sp. isolated from the rhizospheric soil of Phoenix dactylifera (Date palm tree) and cultured on the large scale solid rice medium yielded a novel compound 1-(4-hydroxy-2,6-dimethoxy-3,5-dimethylphenyl)-2-methyl-1-butanone (>1) and four known compounds; citricin (>2), dihydrocitrinone (>3), 2, 3, 4-trimethyl-5, 7-dihydroxy-2, 3-dihydrobenzofuran (>4) and oricinol (>5). The structures of the isolated compounds were elucidated by MS, 1H, 13C and 2D NMR spectra. Compound (>1) exhibited potent antimicrobial activities against Staphylococcus aureus with MIC values of 2.3 μg mL⁻¹ and significant growth inhibitions of 82.3 ± 3.3 against Candida albicans and of 79.2 ± 2.6 against Candida parapsilosis. This is the first report to isolate metabolites from the fungus Aspergillus found in temperate region date plant rhizospheres.Electronic supplementary materialThe online version of this article (10.1186/s13065-019-0624-5) contains supplementary material, which is available to authorized users.