>Objective: To review and critically analyze the literature for the use of tigecycline for the treatment of urinary tract infections (UTIs). >Data Sources: A search of the MEDLINE database was performed (2004 to July 2013). Search terms included tigecycline, Tygacil, pyelonephritis, cystitis, and urinary tract infections in addition to a manual search of references from the articles retrieved. >Study Selection and Data Exaction: All studies of humans, English-language articles, clinical studies, observational studies, and case reports were evaluated. >Data Synthesis: Fourteen cases of tigecycline use for UTIs were identified. No clinical trials were identified via the search of the MEDLINE database. Twelve of the 14 cases described positive clinical outcomes with use of tigecycline for the treatment of UTI. Microbiological clearance was evaluable in 11 patients, of which 9 patients achieved documented microbiological clearance. None of the patients had mortality attributable to the use of tigecycline for the UTI. Two of the 14 cases reported had patients with subsequent cultures growing tigecycline-resistant organisms. >Conclusion: Case reports have documented clinicalimprovement/success with the use of tigecycline for the treatment of UTIs.However, use of tigecycline for the treatment of UTIs remains controversialbecause of limited data and the lack of randomized control trials demonstratingefficacy. Tigecycline should be avoided for the treatment of UTIs whenwell-established options such as aminoglycosides and β-lactams are available.When alternative options are nonexistent, tigecycline can be considered.
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