First-in-human study assessing safety tolerability and pharmacokinetics of 2-hydroxybenzylamine acetate a selective dicarbonyl electrophile scavenger in healthy volunteers

摘要

Background2-Hydroxybenzylamine (2-HOBA) is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles. It is currently being developed for use as a nutritional supplement to help maintain good health and protect against the development of conditions associated with dicarbonyl electrophile formation, such as the cognitive decline associated with Mild Cognitive Impairment and Alzheimer’s disease.