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美国卫生研究院文献>BMC Developmental Biology
>Expression of pair rule gene orthologs in the blastoderm of a myriapod: evidence for pair rule-like mechanisms?
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Expression of pair rule gene orthologs in the blastoderm of a myriapod: evidence for pair rule-like mechanisms?
BackgroundA hallmark of Drosophila segmentation is the stepwise subdivision of the body into smaller and smaller units, and finally into the segments. This is achieved by the function of the well-understood segmentation gene cascade. The first molecular sign of a segmented body appears with the action of the pair rule genes, which are expressed as transversal stripes in alternating segments. Drosophila development, however, is derived, and in most other arthropods only the anterior body is patterned (almost) simultaneously from a pre-existing field of cells; posterior segments are added sequentially from a posterior segment addition zone. A long-standing question is to what extent segmentation mechanisms known from Drosophila may be conserved in short-germ arthropods. Despite the derived developmental modes, it appears more likely that conserved mechanisms can be found in anterior patterning.
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