Paralysis and delayed Z-disc formation in the Xenopus tropicalis unc45b mutant dicky ticker

摘要

BackgroundThe protein components of mature skeletal muscle have largely been characterized, but the mechanics and sequence of their assembly during normal development remain an active field of study. Chaperone proteins specific to sarcomeric myosins have been shown to be necessary in zebrafish and invertebrates for proper muscle assembly and function.