Effect of BRAF mutational status on expression profiles in conventional papillary thyroid carcinomas

摘要

BackgroundWhereas 40 % to 70 % of papillary thyroid carcinomas (PTCs) are characterized by a BRAF mutation (BRAF^mut), unified biomarkers for the genetically heterogeneous group of BRAF wild type (BRAF^wt) PTCs are not established yet. Using state-of-the-art technology we compared RNA expression profiles between conventional BRAF^wt and BRAF^mut PTCs.